Association of Epstein–Barr Virus and Cytomegalovirus Infections with Esophageal Carcinoma

Background: Given the fact that viral infections play an important role, either directly or indirectly, in around 20 percent of human cancers, this study aimed at investigating potential association Epstein–Barr virus (EBV) and cytomegalovirus (CMV) esophageal cancer is sixth most common cause cancer-related deaths. Methods: In case-control study, a total 200 paraffin-embedded biopsies cancerous benign tissues were gathered from biopsy bank Imam Reza Hospital, Tabriz, Iran 2017. All samples first deparaffinized, then subjected to commercial DNA extraction. The quality extracted was evaluated by amplification beta globulin gene. Identification EBV CMV performed using primers designed for EBER region immediate early (IE) genome, respectively. Results: mean age subjects test control groups 52.2 (17.1) 59.9 (18.9), distribution gender (male/female) patient 54/46 53/47, Our results showed frequency (P < 0.001) statistically higher than group. Moreover, group rate significantly adenocarcinomas (EAC) sample (12 out 70) squamous cell carcinomas (ESCC) (0 30) = 0.016) but, ESCC group, 17 30 positive which comparison with EAC patients (1 0.001). Conclusions: Findings indicated might be contributed pathogenesis types carcinoma, respectively, although further studies are warranted.